1. Second Life keeps going, marketing as a game. Not much changes.
2. OpenSim gets a couple middleware player coming into the market with a great business offerings and adoptions of OpenSim by business and universities continue to bloom.
3. Star Wars: The Old Republic is a smash hit.
4. World of Warcraft slowly wanes, losing another 2 - 3 million customers. That said, even at 7 million customers, Blizzard's done a fine job at retaining paying subscribers.
5. Diaspora gets bought or majorly funded.
6. Google+ fades away in Google's streak of closing down interesting projects and trying to make everything ad-driven rather than seek additional revenue models for different products.
7. Multi-player Augmented Reality games catch on, a little. A movie will come out and use one of them for a cool, but under-noticed and under-appreciated ad campaign.
8. Apple continues to lose market share to competitors in mobile and tablet markets, because as easy as it is to point at old Star Trek episodes and say, "Oooh, we should make THAT device!" apparently Steve Jobs was the only one at Apple who forced it to happen.
9. Politicians get hands on with social media for their political campaigns. Building on what exists, politicians will go more and more direct with constituents.
10. The RIAA / MPAA will lose a landmark copyright case as they've pushed free speech issues too far.
11. Net Neutrality regulations put forward by the FCC continue to be upheld by the courts.
Bonus: The world doesn't end because of the Mayan calendar. It's a frigging round wheel calendar; it's mean to repeat, stupid. :)